Kev Tshawb Fawb Tseeb: Hydrogel Dressings muaj NMN tuaj yeem ua kom nrawm kho cov kab mob ntshav qab zib

Txheej txheem cej luam:

●Hydrogel hnav khaub ncaws yog ib tug matrix siv los npog qhov txhab. Nws tuaj yeem tsim cov gel thiab nqus cov qhov txhab zais, ua kom lub qhov txhab moist thiab txhawb kev kho qhov txhab. Hydrogel hnav khaub ncaws yog ib qho matrix siv los npog qhov txhab. Nws tuaj yeem tsim cov gel thiab nqus cov qhov txhab zais, ua kom lub qhov txhab moist thiab txhawb kev kho qhov txhab. Tsis ntev los no, cov kws tshawb fawb pom tias hydrogel hnav khaub ncaws ntxiv nrog NMN (nicotinamide mononucleotide) tuaj yeem ua kom lub qhov txhab zoo thiab kho cov tawv nqaij tuab hauv cov nas mob ntshav qab zib.

●NMN-muaj hydrogel hnav khaub ncaws ua kom lub qhov txhab zoo nyob rau hauv cov kab mob ntshav qab zib nas qauv nrog cov tawv nqaij raug mob.

● Ntxiv cov koob tshuaj NMN siab rau hydrogel hnav khaub ncaws ua rau cov synthesis ntawm daim tawv nqaij collagen, cov txheej txheem protein ntawm daim tawv nqaij thiab cov ntaub so ntswg sib txuas, thaum lub qhov txhab kho.

●Gene kev ua ntawm daim tawv nqaij regeneration proteins-VEGF thiab TGF-ꞵ nce nrog nce koob tshuaj NMN hauv hydrogel hnav khaub ncaws.

Cov kev tshawb fawb qhia tau hais tias qhov txhab ntawm cov neeg mob ntshav qab zib feem ntau muaj teeb meem kho, thiab cov kab mob uas muaj teeb meem yog qhov nyuaj rau kho. Qhov no yog vim hais tias oxidative kev nyuaj siab uas ua los ntawm cov reactive oxygen-muaj cov molecules heev (xws li, reactive oxygen hom) nyob rau hauv lub rwj qhov chaw ua rau lub qhov txhab kho thiab ulcer daws teeb meem nyuaj.

Tam sim no, cov kws kho mob feem ntau siv hydrogel hnav khaub ncaws raws li kev tiv thaiv kab mob los kho cov kab mob ntshav qab zib, tab sis txog rau tam sim no, tsis muaj kev sim tshuaj ntsuam xyuas seb hydrogel hnav khaub ncaws uas muaj cov tshuaj antioxidant NMN tuaj yeem ua kom lawv kho tau zoo.

Cov kws tshawb fawb los ntawm Fudan University tau luam tawm ib tsab xov xwm hauv phau ntawv journal "Biomedicine thiab Drug Therapy" qhia tias kev siv NMN-ntxiv hydrogel hnav khaub ncaws matrix rau cov mob ntshav qab zib tuaj yeem ua kom lub qhov txhab zoo hauv cov nas mob ntshav qab zib. Tsis tas li ntawd, hauv hydrogel matrices uas muaj cov koob tshuaj ntau ntawm NMN, tus nqi thiab tuab ntawm daim tawv nqaij collagen synthesis tau nce thaum lub sijhawm kho. Ib yam li ntawd, raws li koob tshuaj NMN nce, cov haujlwm ntawm -VEGF thiab TGF-ꞵ, uas ua lub luag haujlwm tseem ceeb hauv kev tsim cov tawv nqaij, kuj nce ntxiv.

Cov kev tshawb pom qhia tias ntxiv NMN rau hydrogel hnav khaub ncaws muab ib txoj hauv kev zoo thiab raug nqi kom nrawm kho.

1. NMN txhawb cov tawv nqaij collagen synthesis thiab accelerates ntshav qab zib qhov txhab zoo.
Txhawm rau kuaj seb puas ntxiv NMN rau hydrogel hnav khaub ncaws tuaj yeem ua kom lub qhov txhab zoo nyob hauv cov neeg mob ntshav qab zib, cov kws tshawb fawb tau ntxiv cov tshuaj sib txawv ntawm NMN rau hydrogel. Nyob rau tib lub sijhawm, lawv tau siv NMN-muaj hydrogel hnav khaub ncaws rau cov nas txhaj tshuaj streptozotocin, ntshav qab zib inducer, thiab nrog cov qhov txhab ua tiav ntawm 1 cm inch ntawm lawv nraub qaum.

Kev sim tau pom tias hydrogel hnav khaub ncaws uas muaj cov koob tshuaj ntau ntawm NMN tuaj yeem ua kom lub qhov txhab zoo, thiab qhov mob ceev yog li 30% sai dua li hydrogel hnav khaub ncaws tsis muaj NMN. Cov txiaj ntsig no qhia tau tias kev hnav khaub ncaws hydrogel uas muaj NMN tuaj yeem pib kho sai dua li hydrogel hnav khaub ncaws yam tsis muaj NMN.

(Liang et al., 2023 | Kev Kho Mob Biomedicine & Pharmacotherapy) NMN-loaded hydrogel hnav khaub ncaws siv rau qhov txhab hauv cov nas mob ntshav qab zib kom kho. Piv nrog rau tsis muaj kev kho mob (kab dub) thiab kev kho mob hnav khaub ncaws hydrogel yam tsis muaj NMN (kab liab), NMN-loaded hydrogel daim ntawv thov (kab daj) ua kom ceev cov ntshav qab zib qhov txhab zoo.

Vim hais tias ntxiv NMN rau hydrogel hnav khaub ncaws tuaj yeem ua kom lub qhov txhab zoo, cov kws tshawb fawb tau nrhiav los txiav txim seb NMN ua kom nrawm kho los ntawm kev txhawb nqa collagen synthesis thiab ua rau cov tawv nqaij txheej txheej sab nraud (epidermis).
Interestingly, los ntawm kev sib piv cov hydrogel hnav khaub ncaws pab pawg neeg uas muaj NMN thiab hnav khaub ncaws tsis muaj NMN thaum lub sij hawm kho, cov kws tshawb fawb pom tias nce koob tshuaj NMN hauv hydrogel hnav khaub ncaws tuaj yeem txhawb nqa collagen synthesis. Interestingly, los ntawm kev sib piv cov hydrogel hnav khaub ncaws pab pawg neeg uas muaj NMN thiab hnav khaub ncaws tsis muaj NMN thaum lub sij hawm kho, cov kws tshawb fawb pom tias nce koob tshuaj NMN hauv hydrogel hnav khaub ncaws tuaj yeem txhawb nqa collagen synthesis. Tsis tas li ntawd, NMN-muaj hydrogel hnav khaub ncaws nce ntawm daim tawv nqaij epidermal thickness thaum lub sij hawm kho. Cov txiaj ntsig no qhia tau hais tias ntxiv NMN rau hydrogel hnav khaub ncaws tuaj yeem txhawb nqa collagen synthesis thiab nce epidermal thickness, yog li ua kom lub qhov txhab zoo.

(Liang et al., 2023 | Kev Kho Mob Biomedicine & Pharmacotherapy) Siv NMN-loaded hydrogel hnav khaub ncaws rau cov mob ntshav qab zib qhov txhab ua kom cov tuab ntawm daim tawv nqaij txheej txheej txheej txheej sab nraud. Ib koob tshuaj NMN siab ntxiv rau hydrogel hnav khaub ncaws (checkered bar) ua rau cov kab mob epidermal nce ntau dua li tsis muaj kev kho mob (grey bar qhia xoom tuab) thiab ntxiv cov tawv nqaij loj hlob txhawb cov protein, recombinant tib neeg cov txheej txheem fibroblast kev loj hlob (rh-bFGF; dub bar) .
Nws yog ib qho tsim nyog sau cia tias kev siv cov tshuaj hydrogel uas muaj NMN rau cov mob ntshav qab zib mellitus kuj tseem tuaj yeem ua kom cov tuab ntawm cov txheej txheej sab nraud ntawm daim tawv nqaij. Nws yog ib qho tsim nyog sau cia tias kev siv cov tshuaj hydrogel uas muaj NMN rau cov mob ntshav qab zib mellitus kuj tseem tuaj yeem ua kom cov tuab ntawm cov txheej txheej sab nraud ntawm daim tawv nqaij. Hauv kev hnav khaub ncaws hydrogel (checkered bar) ntxiv nrog cov koob tshuaj ntau ntawm NMN, cov kab mob epidermal tau nce ntau piv nrog cov tshuaj tsis kho hydrogel hnav khaub ncaws (piv txwv li 0). Tsis tas li ntawd xwb, daim tawv nqaij txhawb kev loj hlob ntawm cov protein kuj tau ntxiv, Recombinant human basic fibroblast growth factor (dub bar).

(Liang et al., 2023 | Kev Kho Mob Biomedicine & Pharmacotherapy) Ntxiv NMN rau daim ntawv thov kev hnav khaub ncaws hydrogel txhim kho kev ua kom cov noob rau ntawm daim tawv nqaij txhawb nqa cov proteins VEGF thiab TGF-ꞵ. Daim duab ntawm sab laug) Muab piv rau rh-bFGF (black bar) thiab tsis muaj kev kho mob (grey bar), ntau npaum li cas NMN ntxiv rau hydrogels (checkered bar) nce VEGF noob kev ua haujlwm. Daim duab ntawm sab xis) Cov koob tshuaj siab NMN ntxiv rau hydrogels (checkered bar) kuj nce TGF-ꞵ piv rau tsis muaj kev kho mob (cov kab grey).

Kev sim tau pom tias piv nrog hydrogel hnav khaub ncaws tsis muaj NMN, hydrogel hnav khaub ncaws uas muaj NMN yuav luag ob npaug VEGF thiab txhim kho TGF-ꞵ cov noob caj noob ces. Cov ntaub ntawv no qhia tias ntxiv NMN rau hydrogel hnav khaub ncaws tuaj yeem ua kom mob ntshav qab zib qhov txhab zoo los ntawm kev ua kom tawv nqaij loj hlob-txhim kho VEGF thiab TGF-ꞵ.
Raws li tus kws tshawb fawb ntawm qhov kev sim tau hais tias: "Qhov kev tshawb fawb no yog thawj zaug tshaj tawm tias hydrogel hnav khaub ncaws ntxiv nrog NMN tuaj yeem txhawb kev kho cov mob ko taw hauv cov neeg mob ntshav qab zib.

2. NMN tuaj yeem siv los ua ib txoj hauv kev tshiab los ua kom cov tawv nqaij zoo.
Rau cov neeg mob ntshav qab zib, cov qhov txhab uas lawv loj tuaj tuaj yeem siv sijhawm ntev los kho thiab tuaj yeem ua mob ntev thiab kho tau nyuaj, tshwj xeeb tshaj yog tias lawv tsim mob ntshav qab zib ko taw. Txawm li cas los xij, cov kev kho mob uas twb muaj lawm, xws li tshuaj pleev tshuaj pleev xim thiab cov txheej txheem tso dej kom tshem tawm cov kua dej los ntawm cov kab mob, yog kim thiab muaj txiaj ntsig tsawg.

Raws li kev pom ntawm ntau yam kev tiv thaiv kev kho mob, tam sim no, thov NMN nrog cov khoom tiv thaiv antioxidant rau hydrogel hnav khaub ncaws los txhawb kev kho qhov txhab tuaj yeem dhau los ua qhov kev kho mob qis dua tshiab los txo cov mob ntshav qab zib thiab rwj. Tsis tas li ntawd, lwm txoj kev tshawb fawb pom tau tias NMN, ua ke nrog NAD + (nicotinamide adenine dinucleotide), lwm hom tshuaj tiv thaiv antioxidant tuaj yeem txhawb cov tawv nqaij kho mob hauv cov nas laus. Raws li kev pom ntawm ntau yam kev kho mob, tam sim no, thov NMN nrog cov khoom antioxidant rau hydrogel hnav khaub ncaws los txhawb kev kho qhov txhab tuaj yeem dhau los.

Raws li cov kab no, ntxiv NMN rau ntau hom qhov txhab yuav dhau los ua ib txoj hauv kev los txhawb kev kho mob yav tom ntej.

XI AN CHEN LANG BIO TECH CO., LTD yog NMN hmoov, NAD + tus neeg muag khoom, peb muab cov khoom lag luam zoo, tuaj yeem dhau qhov kev xeem thib peb, thov xa kev nug rau Email: admin@chenlangbio.com ua yog koj xav yuav NMN.