Daptomycin hmoov

Daptomycin yog los ntawm Streptomyces (S.reseosporus) muab rho tawm los ntawm cov tshuaj tua kab mob cyclic lipopeptide cov qauv tshiab ntawm fermentation broth, nws tsis tsuas yog muaj cov qauv tshuaj tshiab, thiab hom kev ua haujlwm thiab ib qho ntawm cov tshuaj tua kab mob pom zoo sib txawv: nws yog los ntawm cov thauj cov amino acids cuam tshuam lub cell membrane, yog li impeding lub biosynthesis ntawm cov kab mob cell phab ntsa peptidoglycan, hloov cov xwm ntawm cell membrane, tuaj yeem ua rau kev ua haujlwm ntawm cov kab mob cell membrane hauv ntau yam, thiab tua cov kab mob gram zoo.

Ntxiv nrog rau lub luag haujlwm ntawm daptomycin nyob rau hauv kev kho mob feem ntau cuam tshuam cov kab mob gram zoo, nws yog qhov tseem ceeb dua kom muaj cov kab mob hauv vitro pom methicillin resistant (methicillin) hom, vancomycin thiab linezolid resistant cov khoom nrog lub zog ua haujlwm rau cov yam ntxwv no tseem ceeb heev hauv kev kho mob hauv cov neeg mob. mob hnyav. 

Kev tshawb fawb qhia tau hais tias cov tshuaj tua kab mob ntawm kev ua haujlwm zoo ib yam li vancomycin thiab daptomycin, feem ntau muaj cov tshuaj tua kab mob zoo rau cov kab mob Gram zoo, xws li Staphylococcus aureus spp MIC = 0.125 ~ 0.5 g / ml, cov kab mob gram spp MIC = 0.06 ~ 0.5 g / ml, 0.25 MIC = ntawm Enterococcus rau 2 mu g / ml. Daptomycin muaj broad-spectrum tshuaj tua kab mob hauv cov kab mob gram zoo anaerobic ntawm spp. MIC = 0.12, Peptostreptococcus g/ml, spp.MIC = 0.5 ntawm Clostridium g/ml ntawm Lactobacillus spp.MIC = 1 g/ml.